Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase C to Membrane Phosphatidylinositol
نویسندگان
چکیده
Michail Nomikos, Jessica R. Sanders, Dimitris Parthimos, Luke Buntwal, Brian L. Calver, Panagiotis Stamatiadis, Adrian Smith, Matthew Clue, Zili Sideratou, Karl Swann, and F. Anthony Lai From the Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom and the National Center for Scientific Research “Demokritos,” 15310 Aghia Paraskevi, Greece
منابع مشابه
PLCζ causes Ca2+ oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P2
Sperm-specific phospholipase C ζ (PLCζ) activates embryo development by triggering intracellular Ca(2+) oscillations in mammalian eggs indistinguishable from those at fertilization. Somatic PLC isozymes generate inositol 1,4,5-trisphophate-mediated Ca(2+) release by hydrolyzing phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) in the plasma membrane. Here we examine the subcellular source of ...
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